Disorders

Disorders DEFINITION Osteogenisis imperfecta (OI) is ?a r atomic number 18 genetic disorder of collagen tax write-off associated with broad spectrum of musculoskeletal problems, most notably bowing and fractures of the extremities, go across weakness, ligamentous laxity, and spinal deformities.? (Binder, 386). Other collagen-containing extraskeletal tissues, such as the sclerae, the teeth, and the heart valves are also affected to a variable degree. OI has a ? everyday feature of bony fragility associated with defective formation of collagen by osteoblasts and fibroblasts.

? (Smith, 1983, 13) This disease, involving defective development of the connective tissues, is usually the pass on of the autosomal dominant gene, but can also be the result of the autosomal recessive gene. Spontaneous mutations are common and the clinical presentation of the disease remains to be quite broad. (Binder, 386) OI is most commonly referred to as ?brittle bones?, but new(prenominal) names include: fragilitas ossium, hypola...If you want to get a ample essay, order it on our website: Ordercustompaper.com

If you want to get a full essay, wisit our page: write my paper